FBXL13

Across TCGA cell cohorts, FBXL13 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXL13-associated genes across cancer lineages are DYNAP, LRIT2, and PRSS41. Each is linked with FBXL13 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL13-to-partner and partner-to-FBXL13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYNAP grouped by FBXL13-low versus FBXL13-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL13→partner) and Y-score (partner→FBXL13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DYNAP →	+0.141	+4.000	<.001	.008	3	1
BONE	LRIT2 →	+0.005	+4.169	<.001	.008	3	1
BONE	PRSS41 →	+0.051	+4.672	<.001	.001	3	1
BONE	CD300H →	+0.387	+4.000	<.001	.008	3	1
LARGE_INTESTINE	KRT85 →	+0.350	+3.145	<.001	.004	3	1
LARGE_INTESTINE	MDGA2 →	+0.172	+4.439	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

DYNAP by FBXL13 expression — BONE

Explore this box plot interactively →