FBXL12

Across TCGA patient cohorts, FBXL12 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL12-associated genes across cancer lineages are MEK1, PRAS40_pT246, and ATM. Each is linked with FBXL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL12-to-partner and partner-to-FBXL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by FBXL12-low versus FBXL12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL12→partner) and Y-score (partner→FBXL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.371	+2.321	.020	.034	3	1
UCEC	PRAS40_pT246 →	+0.163	+2.128	.030	.010	3	1
UCEC	ATM →	-0.462	-2.807	.019	.003	3	1
UCEC	Di-Ras3 →	-0.169	-3.446	.009	.005	3	1
UCEC	ERK2 →	+0.190	+2.115	.023	.019	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEK1 by FBXL12 expression — UCEC

Explore this box plot interactively →