FBXL12

Across TCGA cell cohorts, FBXL12 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,094 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FBXL12-associated GO terms across cancer lineages are Negative regulation of protein localization to chromatin, Regulation of protein localization to chromatin, and Negative regulation of cilium assembly. Each is linked with FBXL12 in more than 14 cancer types. Because this analysis shows association rather than direction, both FBXL12-to-partner and partner-to-FBXL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to chromatin grouped by FBXL12-low versus FBXL12-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL12→partner) and Y-score (partner→FBXL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of protein localization to chromatin →	+0.168	+1.022	.001	<.001	3	15
SOFT_TISSUE	Regulation of protein localization to chromatin →	+0.114	+0.751	<.001	<.001	3	15
URINARY_TRACT	Negative regulation of cilium assembly →	+0.067	+0.699	.004	.001	3	14
STOMACH	Regulation of macroautophagy →	+0.073	+0.597	<.001	<.001	3	13
BONE	Cytosolic transport →	+0.078	+0.578	.002	<.001	3	13
BONE	Regulation of early endosome to late endosome transport →	+0.108	+0.524	.004	.004	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,094 associations by consensus.

Negative regulation of protein localization to chromatin by FBXL12 expression — LIVER

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