FBXL12

Across TCGA cell cohorts, FBXL12 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FBXL12-associated genes across cancer lineages are SYCN, NKX2-6, and USP17L3. Each is linked with FBXL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL12-to-partner and partner-to-FBXL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYCN grouped by FBXL12-low versus FBXL12-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL12→partner) and Y-score (partner→FBXL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYCN →	+0.047	+5.539	<.001	.003	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	USP17L3 →	+0.012	+4.922	.009	.009	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LARGE_INTESTINE	SCYGR1 →	+0.133	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

SYCN by FBXL12 expression — BLOOD_Leukemia

Explore this box plot interactively →