FBRSL1

Across TCGA patient cohorts, FBRSL1 mutation is significantly associated with the RNA expression of many other genes, with 2,555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBRSL1-associated genes across cancer lineages are LIN7C, HIRIP3, and SLC25A4. Each is linked with FBRSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBRSL1-to-partner and partner-to-FBRSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIN7C grouped by FBRSL1-low versus FBRSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBRSL1→partner) and Y-score (partner→FBRSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIN7C →	+0.616	+2.960	<.001	<.001	3	2
UCEC	HIRIP3 →	+0.456	+2.470	.001	<.001	3	2
UCEC	SLC25A4 →	+0.429	+2.233	.005	.005	3	2
UCEC	AP1S3 →	+0.692	+3.087	<.001	<.001	3	2
UCEC	JAKMIP1 →	+0.772	+3.000	<.001	.001	3	2
UCEC	PPP2R5E →	+0.458	+3.721	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,555 associations by consensus.

LIN7C by FBRSL1 expression — UCEC

Explore this box plot interactively →