FBP1

Across TCGA patient cohorts, FBP1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBP1-associated genes across cancer lineages are eEF2, FOXO3a_pS318_S321, and MEK1. Each is linked with FBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBP1-to-partner and partner-to-FBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by FBP1-low versus FBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBP1→partner) and Y-score (partner→FBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.537	+3.000	.009	.037	3	1
UCEC	FOXO3a_pS318_S321 →	-0.179	-2.990	.013	.036	3	1
UCEC	MEK1 →	+0.541	+3.000	.010	.036	3	1
UCEC	Tuberin →	+0.506	+3.009	.001	.019	3	1
UCEC	VHL →	-1.312	-2.999	<.001	.035	3	1
UCEC	Di-Ras3 →	-0.254	-3.000	.003	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eEF2 by FBP1 expression — UCEC

Explore this box plot interactively →