FBP1

Across TCGA pan-cancer cohorts, FBP1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FBP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FBP1 RNA is repressed in tumor relative to normal tissue. In most cancer types FBP1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and KIRC are the cancer types where FBP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−4.397	<.001	11	view →
KIRP	All	III,IV	−3.830	<.001	11	view →
KIRC	Male	All	−2.224	<.001	11	view →
LUAD	Male	All	−1.996	<.001	9	view →
LUSC	Male	II,III,IV	−3.895	<.001	8	view →
LIHC	Female	II,III,IV	−3.149	<.001	8	view →
BRCA	All	III,IV	+1.481	<.001	6	view →
CHOL	All	All	−4.070	<.001	5	view →
UCEC	All	All	+1.185	.003	2	view →
PRAD	All	All	+0.529	.003	2	view →
STAD	All	All	+1.322	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FBP1–KICH

Open the KICH breakdown →