FBN3

Across TCGA patient cohorts, FBN3 protein abundance is significantly associated with the RNA expression of many other genes, with 6,352 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible FBN3-associated genes across cancer lineages are PRICKLE1, CDC42EP3, and GJA5. Each is linked with FBN3 in more than 4 cancer types. Because this analysis shows association rather than direction, both FBN3-to-partner and partner-to-FBN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBN3 versus PRICKLE1 in BRCA, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBN3→partner) and Y-score (partner→FBN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRICKLE1 →	+0.790	+0.630	<.001	<.001	3	5
GBM	CDC42EP3 →	+0.663	+0.451	.006	.003	3	5
COAD	GJA5 →	+0.883	+0.652	<.001	<.001	3	5
COAD	MEDAG →	+1.367	+0.640	<.001	<.001	3	5
BRCA	PDZRN3 →	+0.799	+0.633	.002	.002	3	5
BRCA	SERPINF1 →	+1.006	+0.767	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,352 associations by consensus.

FBN3 vs PRICKLE1 — BRCA

Explore this scatter interactively →