FBN3

Across TCGA patient cohorts, FBN3 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBN3-associated genes across cancer lineages are c-Kit, MYH11, and Caspase-7-cleavedD198. Each is linked with FBN3 in more than 6 cancer types. Because this analysis shows association rather than direction, both FBN3-to-partner and partner-to-FBN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by FBN3-low versus FBN3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBN3→partner) and Y-score (partner→FBN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	c-Kit →	-0.749	-3.807	<.001	<.001	2	7
STAD	MYH11 →	-1.321	-1.906	.014	.015	3	4
COAD	Caspase-7-cleavedD198 →	+1.032	+2.059	<.001	<.001	3	4
STAD	C-Raf →	+0.118	+2.459	.042	.016	3	4
COAD	ERK2 →	+0.123	+1.209	.018	.013	3	4
UCEC	Tuberin_pT1462 →	+0.128	+0.916	.021	.025	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

c-Kit by FBN3 expression — LUAD

Explore this box plot interactively →