FBN3

Across TCGA cell cohorts, FBN3 mutation is significantly associated with the RNA expression of many other genes, with 2,395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBN3-associated genes across cancer lineages are KCNA6, WRAP73, and SERAC1. Each is linked with FBN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBN3-to-partner and partner-to-FBN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA6 grouped by FBN3-low versus FBN3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBN3→partner) and Y-score (partner→FBN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KCNA6 →	+0.051	+4.087	<.001	.003	2	4
LARGE_INTESTINE	WRAP73 →	+0.646	+2.502	<.001	<.001	3	3
BLOOD_Leukemia	SERAC1 →	+0.533	+3.228	.005	.004	3	3
BLOOD_Leukemia	AOC3 →	+0.446	+2.324	.002	.002	3	3
LARGE_INTESTINE	DHX30 →	+0.576	+1.780	<.001	<.001	3	3
LARGE_INTESTINE	LYG1 →	+0.790	+1.780	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,395 associations by consensus.

KCNA6 by FBN3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →