FBN2

Across TCGA patient cohorts, FBN2 mutation is significantly associated with the total protein of many other genes, with 117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBN2-associated genes across cancer lineages are Caveolin-1, p70-S6K, and CDK1. Each is linked with FBN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBN2-to-partner and partner-to-FBN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by FBN2-low versus FBN2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBN2→partner) and Y-score (partner→FBN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Caveolin-1 →	-0.637	-1.514	<.001	.007	3	4
STAD	p70-S6K →	+0.231	+2.115	.021	.017	3	4
COAD	CDK1 →	+0.259	+2.915	<.001	<.001	3	4
STAD	FoxM1 →	+0.243	+2.201	.019	.031	3	3
STAD	4E-BP1 →	+0.354	+2.115	.002	.017	3	3
LUAD	EGFR_pY1068 →	-0.258	-1.392	.038	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

Caveolin-1 by FBN2 expression — LUSC

Explore this box plot interactively →