FBN2

Across TCGA pan-cancer cohorts, FBN2 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated FBN2 data layer compared with 14 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher FBN2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FBN2 expression acts as an unfavorable survival marker, although some lineages such as COAD and THCA show a favorable association.

BLCA, STAD, and MESO are the cancer types where FBN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.636	0.786	<.001	121	view →
STAD	DFS	Quartile	All	0.370	0.571	.005	101	view →
MESO	OS	Median	All	0.414	0.681	<.001	83	view →
ACC	OS	Tertile	All	0.351	0.890	<.001	82	view →
DLBC	DFS	Quartile	All	0.422	1.000	.006	48	view →
COAD	OS	Median	All	0.875	0.715	.002	32	view →
SARC	OS	Quartile	All	0.717	0.921	<.001	30	view →
HNSC	DFS	Median	All	0.226	0.451	.009	26	view →
THCA	DFS	Median	All	0.928	0.637	<.001	26	view →
KICH	DFS	Median	All	0.620	1.000	.005	25	view →
LUSC	OS	Quartile	All	0.857	0.729	.003	24	view →
LIHC	OS	Median	All	0.453	0.683	.004	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

FBN2–BLCA (OS)

Open the BLCA breakdown →