FBN2

Across TCGA cell cohorts, FBN2 mutation is significantly associated with the RNA expression of many other genes, with 1,120 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBN2-associated genes across cancer lineages are SLCO1C1, HSD17B6, and RNF167. Each is linked with FBN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBN2-to-partner and partner-to-FBN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1C1 grouped by FBN2-low versus FBN2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBN2→partner) and Y-score (partner→FBN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLCO1C1 →	+0.010	+2.263	.004	.008	3	3
BLOOD_Lymphoma	HSD17B6 →	+0.680	+2.658	.002	.002	3	3
LARGE_INTESTINE	RNF167 →	+0.354	+1.721	.004	.003	3	3
LARGE_INTESTINE	SEC11C →	+0.716	+1.721	.002	.003	3	3
LARGE_INTESTINE	TSR1 →	+0.469	+3.459	.006	.001	3	3
LARGE_INTESTINE	MFAP3L →	+0.767	+1.721	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,120 associations by consensus.

SLCO1C1 by FBN2 expression — BLOOD_Lymphoma

Explore this box plot interactively →