FBN1

Across TCGA patient cohorts, FBN1 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,295 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FBN1-associated proteins across cancer lineages are ZYX, TLN1, and TLN1_S2162. Each is linked with FBN1 in more than 9 cancer types. Because this analysis shows association rather than direction, both FBN1-to-partner and partner-to-FBN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBN1 versus ZYX in GBM, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FBN1→partner) and Y-score (partner→FBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZYX →	+0.438	+0.565	<.001	<.001	3	10
UCEC	TLN1 →	+0.510	+1.061	<.001	<.001	3	10
LSCC	TLN1_S2162 →	+0.808	+0.901	<.001	<.001	3	10
OV	POSTN →	+1.324	+1.597	<.001	<.001	3	10
PDAC	RARRES2 →	+0.820	+0.597	<.001	<.001	3	10
GBM	RCN3 →	+0.869	+0.656	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,295 associations by consensus.

FBN1 vs ZYX — GBM

Explore this scatter interactively →