FBN1

Across TCGA pan-cancer cohorts, FBN1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FBN1 data layer compared with 10 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher FBN1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FBN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

MESO, ACC, and BLCA are the cancer types where FBN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.417	0.665	<.001	102	view →
ACC	DFS	Median	All	0.509	0.800	<.001	82	view →
BLCA	OS	Tertile	All	0.501	0.682	.001	75	view →
STAD	OS	Quartile	All	0.339	0.603	.003	47	view →
LGG	OS	Tertile	All	0.729	0.905	<.001	44	view →
KICH	OS	Tertile	III,IV	0.348	1.000	.003	39	view →
UVM	OS	Median	III,IV	0.651	0.933	.004	37	view →
KIRP	OS	Tertile	All	0.891	0.970	.006	36	view →
HNSC	DFS	Quartile	II,III,IV	0.773	0.596	.003	29	view →
LUAD	OS	Tertile	II,III,IV	0.622	0.326	.001	29	view →
THCA	OS	Median	III,IV	0.945	1.000	.005	26	view →
CESC	DFS	Quartile	All	0.730	0.870	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FBN1–MESO (OS)

Open the MESO breakdown →