FBN1

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, FBN1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,480 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FBN1-associated genes across cancer lineages are ISLR, DCN, and COL10A1. Each is linked with FBN1 in more than 8 cancer types. Because this analysis shows association rather than direction, both FBN1-to-partner and partner-to-FBN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBN1 versus ISLR in OV, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBN1→partner) and Y-score (partner→FBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVISLR →+1.392+0.812<.001<.00139
OVDCN →+1.870+1.250<.001<.00139
OVCOL10A1 →+2.175+0.720<.001<.00139
OVDDR2 →+1.571+1.033<.001<.00139
OVFSTL1 →+1.366+0.980<.001<.00139
BRCAMSRB3 →+1.111+0.807<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 10,480 associations by consensus.

FBN1 vs ISLR — OV

Per-sample scatter of FBN1 vs ISLR in OV (Pearson r = 0.62).

Explore this scatter interactively →

Exploration