FBN1

Across TCGA cell cohorts, FBN1 mutation is significantly associated with the RNA expression of many other genes, with 615 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FBN1-associated genes across cancer lineages are OR52B6, SH3GL2, and ASIC5. Each is linked with FBN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBN1-to-partner and partner-to-FBN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52B6 grouped by FBN1-low versus FBN1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBN1→partner) and Y-score (partner→FBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR52B6 →	+0.069	+3.714	.001	.002	3	3
LARGE_INTESTINE	SH3GL2 →	+0.990	+1.969	<.001	<.001	3	3
BREAST	ASIC5 →	+0.158	+3.437	<.001	.009	3	3
PANCREAS	NAT8B →	+0.085	+2.841	.003	.007	3	2
PANCREAS	CDH7 →	+0.063	+4.722	<.001	<.001	3	2
KIDNEY	DGKB →	+0.180	+3.491	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 615 associations by consensus.

OR52B6 by FBN1 expression — KIDNEY

Explore this box plot interactively →