FBLN2

Across TCGA patient cohorts, FBLN2 mutation is significantly associated with the RNA expression of many other genes, with 3,885 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBLN2-associated genes across cancer lineages are EIF2B2, PARP2, and BUB3. Each is linked with FBLN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBLN2-to-partner and partner-to-FBLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF2B2 grouped by FBLN2-low versus FBLN2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBLN2→partner) and Y-score (partner→FBLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF2B2 →	+0.289	+2.013	.005	.005	3	4
UCEC	PARP2 →	+0.390	+1.632	<.001	<.001	3	4
UCEC	BUB3 →	+0.358	+1.923	<.001	.003	3	4
UCEC	ZCCHC4 →	+0.320	+1.642	<.001	<.001	3	4
UCEC	LLPH →	+0.335	+1.675	.001	<.001	3	4
LIHC	GAPDHP50 →	+0.030	+4.479	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,885 associations by consensus.

EIF2B2 by FBLN2 expression — COAD

Explore this box plot interactively →