FBLN2

Across TCGA pan-cancer cohorts, FBLN2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FBLN2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FBLN2 RNA is repressed in tumor relative to normal tissue. In most cancer types FBLN2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and BLCA are the cancer types where FBLN2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBLN2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−3.281	<.001	10	view →
THCA	Female	II,III,IV	−2.292	<.001	10	view →
BLCA	Male	III,IV	−2.874	<.001	8	view →
HNSC	Female	III,IV	+1.883	.006	7	view →
COAD	Female	II,III,IV	−1.312	<.001	6	view →
BRCA	All	II,III,IV	−1.066	<.001	6	view →
KIRP	All	All	−1.369	<.001	3	view →
LUAD	All	III,IV	+0.864	.007	3	view →
READ	Female	All	−2.735	.002	2	view →
STAD	Female	All	−1.481	.047	2	view →
PRAD	All	All	−0.557	.032	2	view →
CHOL	All	All	+1.355	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FBLN2–KICH

Open the KICH breakdown →