FBLN2

Across TCGA cell cohorts, FBLN2 mutation is significantly associated with the RNA expression of many other genes, with 778 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBLN2-associated genes across cancer lineages are SLC25A31, OR8D2, and TMEM190. Each is linked with FBLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBLN2-to-partner and partner-to-FBLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A31 grouped by FBLN2-low versus FBLN2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBLN2→partner) and Y-score (partner→FBLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC25A31 →	+0.009	+2.380	.006	.009	3	2
LUNG_NSCLC_LUAD	OR8D2 →	+0.032	+2.108	.002	.008	3	2
SKIN	TMEM190 →	+0.432	+4.035	<.001	<.001	3	2
BLOOD_Leukemia	TRAT1 →	+2.734	+3.491	<.001	.009	3	2
BLOOD_Leukemia	OR5M1 →	+0.008	+4.247	<.001	.004	3	2
LARGE_INTESTINE	FBXL4 →	+0.510	+2.502	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 778 associations by consensus.

SLC25A31 by FBLN2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →