FBH1

Across TCGA cell cohorts, FBH1 mutation is significantly associated with the RNA expression of many other genes, with 624 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBH1-associated genes across cancer lineages are DESI1, OR2C1, and FOXE3. Each is linked with FBH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBH1-to-partner and partner-to-FBH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DESI1 grouped by FBH1-low versus FBH1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBH1→partner) and Y-score (partner→FBH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DESI1 →	+0.573	+3.584	<.001	<.001	3	2
LARGE_INTESTINE	OR2C1 →	+0.072	+2.211	.002	.003	3	2
LARGE_INTESTINE	FOXE3 →	+0.098	+2.264	<.001	.005	3	2
OVARY	OR2B3 →	+0.012	+3.339	<.001	.004	3	1
LUNG_NSCLC_LUAD	FOXB2 →	+0.998	+4.681	<.001	.003	3	1
SKIN	SIGLEC11 →	+0.025	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 624 associations by consensus.

DESI1 by FBH1 expression — LARGE_INTESTINE

Explore this box plot interactively →