FATE1

Across TCGA patient cohorts, FATE1 mutation is significantly associated with the RNA expression of many other genes, with 1,452 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FATE1-associated genes across cancer lineages are RN7SKP231, SNORD114-20, and RNU6-958P. Each is linked with FATE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FATE1-to-partner and partner-to-FATE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP231 grouped by FATE1-low versus FATE1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FATE1→partner) and Y-score (partner→FATE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SKP231 →	+0.592	+5.383	<.001	<.001	3	2
LUAD	SNORD114-20 →	+0.804	+4.303	<.001	.009	3	2
LUAD	RNU6-958P →	+0.503	+4.859	<.001	.004	3	2
LUAD	VN1R69P →	+0.085	+4.730	<.001	.005	3	2
LUAD	MIR3689F →	+0.566	+5.523	<.001	.001	3	2
COAD	RNA5SP41 →	+0.518	+5.122	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,452 associations by consensus.

RN7SKP231 by FATE1 expression — LUAD

Explore this box plot interactively →