FAT3

Across TCGA patient cohorts, FAT3 mutation is significantly associated with the RNA expression of many other genes, with 11,998 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAT3-associated genes across cancer lineages are CDKN3, NDUFA12, and NCAPG. Each is linked with FAT3 in more than 8 cancer types. Because this analysis shows association rather than direction, both FAT3-to-partner and partner-to-FAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN3 grouped by FAT3-low versus FAT3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAT3→partner) and Y-score (partner→FAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDKN3 →	+0.613	+1.903	<.001	<.001	3	9
LUAD	NDUFA12 →	+0.267	+1.081	<.001	<.001	3	9
BRCA	NCAPG →	+1.084	+2.496	<.001	<.001	3	8
UCEC	GINS2 →	+0.615	+1.232	<.001	<.001	3	8
BRCA	RAI2 →	-0.863	-1.773	.002	.002	3	8
BRCA	CDCA8 →	+0.945	+1.903	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,998 associations by consensus.

CDKN3 by FAT3 expression — BRCA

Explore this box plot interactively →