FAT3

Across TCGA pan-cancer cohorts, FAT3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FAT3 data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAT3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAT3 expression acts as an unfavorable survival marker, although some lineages such as ACC and KIRC show a favorable association.

UCEC, MESO, and UVM are the cancer types where FAT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.448	0.667	<.001	86	view →
MESO	OS	Median	All	0.274	0.486	<.001	84	view →
UVM	DFS	Tertile	All	0.384	0.888	<.001	44	view →
ACC	DFS	Tertile	III,IV	0.653	0.153	.001	40	view →
KIRC	DFS	Tertile	All	0.720	0.561	.005	30	view →
STAD	OS	Median	II,III,IV	0.502	0.631	.005	25	view →
SKCM	OS	Median	II,III,IV	0.305	0.500	.002	24	view →
GBM	DFS	Quartile	All	0.486	0.232	.012	12	view →
BRCA	OS	Quartile	IV	0.930	0.258	.006	12	view →
PRAD	DFS	Tertile	All	0.891	0.734	.016	12	view →
THCA	OS	Quartile	II,III,IV	0.850	1.000	.022	8	view →
LIHC	DFS	Median	III,IV	0.527	0.208	.009	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FAT3–UCEC (DFS)

Open the UCEC breakdown →