FAT3

Across TCGA cell cohorts, FAT3 mutation is significantly associated with the RNA expression of many other genes, with 3,775 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAT3-associated genes across cancer lineages are ASCC1, MRPS5, and TAF1C. Each is linked with FAT3 in more than 4 cancer types. Because this analysis shows association rather than direction, both FAT3-to-partner and partner-to-FAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASCC1 grouped by FAT3-low versus FAT3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAT3→partner) and Y-score (partner→FAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASCC1 →	+0.477	+1.180	.002	.003	3	5
SOFT_TISSUE	MRPS5 →	+0.540	+3.214	.002	.006	3	4
LUNG_NSCLC_LUAD	TAF1C →	+0.372	+1.497	.004	<.001	3	4
OVARY	SAAL1 →	+0.695	+2.115	<.001	.007	3	4
LARGE_INTESTINE	SCO1 →	+0.623	+1.396	<.001	<.001	3	4
BLOOD_Leukemia	DIS3L2 →	+0.441	+1.877	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,775 associations by consensus.

ASCC1 by FAT3 expression — LARGE_INTESTINE

Explore this box plot interactively →