FAT1

Across TCGA pan-cancer cohorts, FAT1 Mutation is linked to patient survival in 15 of 34 cancer types, making it a survival-associated FAT1 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAT1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated FAT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, LIHC, and READ are the cancer types where FAT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.908	0.426	.001	36	view →
LIHC	DFS	Median	II,III,IV	0.070	0.420	<.001	15	view →
READ	OS	Median	III,IV	0.644	0.932	<.001	14	view →
SKCM	OS	Median	III,IV	0.733	0.361	.007	13	view →
PCPG	OS	Median	All	0.524	0.975	<.001	12	view →
LAML	DFS	Median	All	0.028	0.572	<.001	12	view →
PAAD	OS	Median	All	0.112	0.640	.004	12	view →
SARC	DFS	Median	All	0.105	0.636	<.001	6	view →
PRAD	DFS	Median	All	0.171	0.890	<.001	6	view →
ESCA	OS	Median	III,IV	0.252	0.580	.030	6	view →
LUAD	OS	Median	IV	0.153	0.714	.012	6	view →
HNSC	DFS	Median	II,III,IV	0.444	0.701	.007	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

FAT1–UCEC (OS)

Open the UCEC breakdown →