FAT1

Across TCGA pan-cancer cohorts, FAT1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of FAT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FAT1 RNA is repressed in tumor relative to normal tissue. In most cancer types FAT1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, HNSC, and LIHC are the cancer types where FAT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.722	<.001	10	view →
HNSC	All	III,IV	+1.843	<.001	10	view →
LIHC	Female	II,III,IV	+2.175	<.001	9	view →
LUAD	Male	II,III,IV	+1.798	<.001	9	view →
LUSC	Female	All	+1.757	<.001	8	view →
THCA	All	II,III,IV	−0.909	<.001	7	view →
STAD	Male	II,III,IV	+1.838	<.001	6	view →
BRCA	All	III,IV	−1.358	<.001	6	view →
KIRP	Female	All	+1.295	.001	6	view →
COAD	Male	All	+1.014	<.001	5	view →
CHOL	Male	All	+2.895	<.001	3	view →
READ	All	III,IV	+1.920	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

FAT1–KICH

Open the KICH breakdown →