FAT1

Across TCGA pan-cancer cohorts, FAT1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAT1 data layer compared with 25 for mass-spec protein and 15 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FAT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where FAT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.320	0.575	.001	41	view →
LUAD	OS	Quartile	II,III,IV	0.256	0.795	.001	11	view →
LSCC	DFS	Tertile	II,III,IV	0.520	0.864	.010	8	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
HNSC	DFS	Median	II,III,IV	0.966	0.907	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAT1–PDAC (DFS)

Open the PDAC breakdown →