FAT1

Across TCGA patient cohorts, FAT1 mutation is significantly associated with the total protein of many other genes, with 109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAT1-associated genes across cancer lineages are TIGAR, Caspase-7-cleavedD198, and PREX1. Each is linked with FAT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FAT1-to-partner and partner-to-FAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by FAT1-low versus FAT1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAT1→partner) and Y-score (partner→FAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TIGAR →	+0.106	+1.528	.005	.007	3	4
COAD	Caspase-7-cleavedD198 →	+1.066	+2.338	<.001	<.001	3	4
SKCM	PREX1 →	-0.190	-1.362	.048	.032	3	4
COAD	TSC1 →	-0.372	-2.392	<.001	<.001	3	4
COAD	C-Raf →	+0.101	+1.841	.012	.012	3	4
LUSC	MIG-6 →	+0.084	+1.331	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

TIGAR by FAT1 expression — LUSC

Explore this box plot interactively →