FAT1

Across TCGA cell cohorts, FAT1 mutation is significantly associated with the RNA expression of many other genes, with 2,180 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAT1-associated genes across cancer lineages are TXNDC12, ENO2, and SCN2A. Each is linked with FAT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FAT1-to-partner and partner-to-FAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNDC12 grouped by FAT1-low versus FAT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAT1→partner) and Y-score (partner→FAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TXNDC12 →	+0.387	+1.631	.002	.004	3	3
BLOOD_Leukemia	ENO2 →	+1.896	+2.444	<.001	<.001	3	3
BLOOD_Leukemia	SCN2A →	+0.451	+3.321	.001	<.001	3	3
BLOOD_Leukemia	LACC1 →	-0.712	-2.656	.005	.002	3	3
LARGE_INTESTINE	LYG1 →	+0.976	+2.290	<.001	<.001	3	3
LARGE_INTESTINE	MED31 →	+0.750	+2.290	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,180 associations by consensus.

TXNDC12 by FAT1 expression — LARGE_INTESTINE

Explore this box plot interactively →