FASTKD3

Across TCGA patient cohorts, FASTKD3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FASTKD3-associated genes across cancer lineages are C-Raf, FoxM1, and PCNA. Each is linked with FASTKD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FASTKD3-to-partner and partner-to-FASTKD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FASTKD3-low versus FASTKD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FASTKD3→partner) and Y-score (partner→FASTKD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.163	+1.415	.002	.046	3	3
UCEC	FoxM1 →	+0.223	+2.169	.021	.003	3	2
UCEC	PCNA →	+0.210	+1.765	.009	.014	3	2
UCEC	PTEN →	-0.335	-2.999	.024	.035	3	2
UCEC	EGFR_pY1068 →	-0.193	-1.765	.040	.014	3	1
UCEC	A-Raf_pS299 →	-0.089	-1.700	.047	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

C-Raf by FASTKD3 expression — UCEC

Explore this box plot interactively →