FASTK

Across TCGA cell cohorts, FASTK mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FASTK-associated genes across cancer lineages are GHRH, FSHB, and NXNL1. Each is linked with FASTK in more than 1 cancer types. Because this analysis shows association rather than direction, both FASTK-to-partner and partner-to-FASTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by FASTK-low versus FASTK-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FASTK→partner) and Y-score (partner→FASTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GHRH →	+0.296	+5.196	<.001	.005	3	1
BLOOD_Lymphoma	FSHB →	+0.012	+5.247	<.001	.001	3	1
BREAST	NXNL1 →	+0.050	+4.963	<.001	.001	3	1
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1
LUNG_NSCLC_LUAD	DIPK2B →	+0.044	+4.312	.004	.005	3	1
LUNG_NSCLC_LUAD	P2RY13 →	+0.017	+4.312	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GHRH by FASTK expression — OVARY

Explore this box plot interactively →