FASTK

Across TCGA pan-cancer cohorts, FASTK RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of FASTK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where FASTK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FASTK is over-expressed in tumor.

KIRP, COAD, and LIHC are the cancer types where FASTK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FASTK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.669	<.001	11	view →
COAD	Female	All	+0.580	<.001	10	view →
LIHC	Female	II,III,IV	+1.585	<.001	9	view →
LUAD	Female	III,IV	+0.945	<.001	9	view →
BLCA	All	All	+0.671	<.001	9	view →
LUSC	Male	II,III,IV	+0.857	<.001	8	view →
BRCA	All	III,IV	+0.443	<.001	6	view →
CHOL	All	All	+1.662	<.001	5	view →
STAD	All	II,III,IV	+0.429	.003	5	view →
UCEC	All	All	+0.396	.006	4	view →
HNSC	All	IV	+0.348	.006	4	view →
KICH	Female	II,III,IV	+0.531	.006	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

FASTK–KIRP

Open the KIRP breakdown →