FARSA

Across TCGA patient cohorts, FARSA mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FARSA-associated genes across cancer lineages are Akt_pT308, PCNA, and JNK_pT183_Y185. Each is linked with FARSA in more than 2 cancer types. Because this analysis shows association rather than direction, both FARSA-to-partner and partner-to-FARSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by FARSA-low versus FARSA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FARSA→partner) and Y-score (partner→FARSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.534	+2.321	.040	.006	3	3
UCEC	PCNA →	+0.179	+2.999	.044	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.162	-3.169	.020	.019	3	1
UCEC	p62 Lck ligand →	+0.284	+3.169	.034	.018	3	1
UCEC	Rab11 →	-0.121	-1.807	.042	.027	3	1
UCEC	TIGAR →	+0.151	+1.833	.016	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Akt_pT308 by FARSA expression — UCEC

Explore this box plot interactively →