FARS2

Across TCGA cell cohorts, FARS2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FARS2-associated genes across cancer lineages are TBC1D3, LCE1C, and CTXN3. Each is linked with FARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FARS2-to-partner and partner-to-FARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3 grouped by FARS2-low versus FARS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FARS2→partner) and Y-score (partner→FARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D3 →	+0.061	+3.688	<.001	.002	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	CTXN3 →	+0.019	+5.201	<.001	.006	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

TBC1D3 by FARS2 expression — LARGE_INTESTINE

Explore this box plot interactively →