FAP

Across TCGA patient cohorts, FAP mutation is significantly associated with the RNA expression of many other genes, with 2,962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAP-associated genes across cancer lineages are MPG, PPP3CC, and EXOSC9. Each is linked with FAP in more than 2 cancer types. Because this analysis shows association rather than direction, both FAP-to-partner and partner-to-FAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPG grouped by FAP-low versus FAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAP→partner) and Y-score (partner→FAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MPG →	+0.345	+2.258	.001	<.001	3	3
UCEC	PPP3CC →	+0.629	+2.065	<.001	<.001	3	3
SKCM	EXOSC9 →	+0.386	+2.208	.002	<.001	3	3
UCEC	KDM4B →	+0.356	+1.447	.001	.003	3	3
LUSC	SCLY →	+0.254	+3.295	<.001	<.001	3	3
UCEC	CXCL9 →	+1.958	+2.280	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,962 associations by consensus.

MPG by FAP expression — UCEC

Explore this box plot interactively →