FAP

Across TCGA pan-cancer cohorts, FAP RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of FAP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAP is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where FAP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+4.233	<.001	12	view →
LUAD	Male	III,IV	+2.686	<.001	11	view →
COAD	Male	III,IV	+2.586	<.001	11	view →
BLCA	All	IV	+2.011	<.001	10	view →
STAD	Male	II,III,IV	+1.988	<.001	10	view →
LIHC	Female	All	+0.669	<.001	9	view →
LUSC	All	II,III,IV	+1.556	<.001	8	view →
KIRC	Male	All	+0.751	<.001	8	view →
KIRP	All	III,IV	+0.882	.033	7	view →
BRCA	All	III,IV	+1.915	<.001	6	view →
READ	Male	All	+3.233	.017	4	view →
CHOL	All	All	+2.026	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

FAP–HNSC

Open the HNSC breakdown →