FAP

Across TCGA cell cohorts, FAP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,959 significant associations in total. CNS shows the largest number of these associations.

The most reproducible FAP-associated GO terms across cancer lineages are Substrate adhesion-dependent cell spreading, Wound healing, and Protein localization to endoplasmic reticulum. Each is linked with FAP in more than 9 cancer types. Because this analysis shows association rather than direction, both FAP-to-partner and partner-to-FAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Substrate adhesion-dependent cell spreading grouped by FAP-low versus FAP-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAP→partner) and Y-score (partner→FAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Substrate adhesion-dependent cell spreading →	+0.199	+2.921	.001	.007	2	10
BONE	Wound healing →	+0.167	+3.864	<.001	<.001	3	9
BONE	Protein localization to endoplasmic reticulum →	+0.139	+3.985	.001	<.001	3	9
BREAST	Regulation of collagen catabolic process →	-0.259	-1.531	<.001	<.001	3	8
BREAST	Negative regulation of cytokine production →	+0.071	+1.549	<.001	<.001	3	8
BREAST	Viral life cycle →	+0.085	+1.391	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,959 associations by consensus.

Substrate adhesion-dependent cell spreading by FAP expression — BONE

Explore this box plot interactively →