FAP

Across TCGA cell cohorts, FAP mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAP-associated genes across cancer lineages are HDGFL1, TCP10L2, and SLC22A11. Each is linked with FAP in more than 1 cancer types. Because this analysis shows association rather than direction, both FAP-to-partner and partner-to-FAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HDGFL1 grouped by FAP-low versus FAP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAP→partner) and Y-score (partner→FAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HDGFL1 →	+0.150	+2.493	<.001	.003	3	2
LUNG_SCLC	TCP10L2 →	+0.617	+3.750	.005	.003	3	1
LUNG_SCLC	SLC22A11 →	+0.051	+3.409	.003	.009	3	1
LUNG_SCLC	OR10R2 →	+1.099	+3.684	<.001	.001	3	1
LUNG_SCLC	ANTXRL →	+0.042	+3.070	.003	.009	3	1
BLOOD_Lymphoma	PTH →	+0.017	+5.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

HDGFL1 by FAP expression — BLOOD_Leukemia

Explore this box plot interactively →