Across TCGA pan-cancer cohorts, FANK1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FANK1 data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher FANK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FANK1 expression acts as an unfavorable survival marker.

DLBC, SARC, and BRCA are the cancer types where FANK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
SARC	OS	Median	All	0.108	0.839	<.001	12	view →
BRCA	DFS	Median	All	0.112	0.525	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: FANK1 tumor-vs-normal RNA expression · all FANK1 data types