Across TCGA pan-cancer cohorts, FANK1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FANK1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where FANK1 RNA is repressed in tumor relative to normal tissue. In most cancer types FANK1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.
KICH, THCA, and BRCA are the cancer types where FANK1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FANK1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.