Across TCGA patient cohorts, FANK1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANK1-associated genes across cancer lineages are INPP4B, PKC-b-II_pS660, and Smad3. Each is linked with FANK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FANK1-to-partner and partner-to-FANK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANK1→partner) and Y-score (partner→FANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.416	-3.169	.014	.018	3	2
UCEC	PKC-b-II_pS660 →	-0.367	-3.000	.011	.036	2	3
UCEC	Smad3 →	+0.173	+3.000	.029	.036	3	2
UCEC	FOXO3a_pS318_S321 →	-0.142	-3.160	.030	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.266	-2.999	.002	.035	3	1
UCEC	Ku80 →	+0.325	+3.335	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

FANK1 survival (RNA) · tumor vs normal (RNA) · all FANK1 data types