Across TCGA cell cohorts, FANK1 mutation is significantly associated with the mutation status of many other genes, with 707 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FANK1-associated genes across cancer lineages are AKAP17A, ZFYVE27, and SIGLEC12. Each is linked with FANK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FANK1-to-partner and partner-to-FANK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANK1→partner) and Y-score (partner→FANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AKAP17A →	+4.772	+5.339	.004	.004	1	3
LARGE_INTESTINE	ZFYVE27 →	+3.007	+3.584	.008	.008	1	3
LUNG_NSCLC_LUAD	SIGLEC12 →	+4.187	+5.000	.008	.008	1	2
LUNG_NSCLC_LUAD	ELFN2 →	+4.772	+5.339	.004	.004	1	2
LUNG_NSCLC_LUAD	TM4SF4 →	+5.772	+5.772	.002	.002	1	2
LUNG_NSCLC_LUAD	USP19 →	+4.187	+5.000	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 707 associations by consensus.

Exploration

FANK1 survival (RNA) · tumor vs normal (RNA) · all FANK1 data types