Across TCGA patient cohorts, FANCM RNA expression is significantly associated with the protein abundance of many other proteins, with 18,794 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FANCM-associated proteins across cancer lineages are UBR7, FKBP3, and PPP4R3A. Each is linked with FANCM in more than 8 cancer types. Because this analysis shows association rather than direction, both FANCM-to-partner and partner-to-FANCM results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCM→partner) and Y-score (partner→FANCM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBR7 →	+0.443	+0.591	<.001	<.001	3	9
OV	FKBP3 →	+0.456	+0.540	<.001	<.001	3	9
GBM	PPP4R3A →	+0.304	+0.509	<.001	<.001	3	8
GBM	SMC2 →	+0.612	+0.614	.001	<.001	3	8
UCEC	SSRP1 →	+0.462	+0.588	<.001	<.001	3	8
LSCC	SUPT16H →	+0.386	+0.573	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,794 associations by consensus.

Exploration

FANCM survival (RNA) · tumor vs normal (RNA) · all FANCM data types