Across TCGA cell cohorts, FANCG mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FANCG-associated genes across cancer lineages are OR4S2, LYPD2, and BOD1L2. Each is linked with FANCG in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCG-to-partner and partner-to-FANCG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCG→partner) and Y-score (partner→FANCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR4S2 →	+0.020	+5.285	<.001	.003	3	1
BLOOD_Leukemia	LYPD2 →	+0.060	+4.152	.004	.009	3	1
BLOOD_Leukemia	BOD1L2 →	+0.032	+4.276	<.001	.007	3	1
LARGE_INTESTINE	PNMA3 →	+0.166	+3.781	<.001	.003	3	1
LARGE_INTESTINE	CLEC2A →	+0.069	+2.925	.001	.007	3	1
LARGE_INTESTINE	SPANXN3 →	+0.120	+2.974	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

FANCG survival (RNA) · tumor vs normal (RNA) · all FANCG data types