FANCE

Across TCGA patient cohorts, FANCE mutation is significantly associated with the RNA expression of many other genes, with 201 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCE-associated genes across cancer lineages are SNORD114-25, RN7SL447P, and RN7SL654P. Each is linked with FANCE in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCE-to-partner and partner-to-FANCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD114-25 grouped by FANCE-low versus FANCE-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCE→partner) and Y-score (partner→FANCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SNORD114-25 →	+0.572	+6.018	<.001	.002	3	2
UCEC	RN7SL447P →	+0.269	+2.740	<.001	.002	3	2
UCEC	RN7SL654P →	+0.120	+2.957	.003	.009	3	2
UCEC	ZNF519P4 →	+0.391	+3.129	<.001	.002	3	2
COAD	RNA5SP86 →	+0.847	+7.142	<.001	<.001	3	2
COAD	LINC02337 →	+0.233	+6.917	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 201 associations by consensus.

SNORD114-25 by FANCE expression — BLCA

Explore this box plot interactively →