FANCE

Across TCGA patient cohorts, FANCE mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCE-associated genes across cancer lineages are p62 Lck ligand, AR, and CD20. Each is linked with FANCE in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCE-to-partner and partner-to-FANCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by FANCE-low versus FANCE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCE→partner) and Y-score (partner→FANCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.452	+2.817	.016	.036	3	1
UCEC	AR →	-0.435	-3.000	.044	.037	3	1
UCEC	CD20 →	+0.202	+2.827	.007	.035	3	1
UCEC	MSH6 →	-0.509	-3.000	.007	.037	2	1
UCEC	PDCD4 →	-0.615	-3.000	.023	.037	2	1
UCEC	p27_pT198 →	+0.244	+3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p62 Lck ligand by FANCE expression — UCEC

Explore this box plot interactively →