FANCE

Across TCGA cell cohorts, FANCE RNA expression is significantly associated with the go_rna of many other GO terms, with 3,734 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FANCE-associated GO terms across cancer lineages are Interstrand cross-link repair, Negative regulation of RNA export from nucleus, and Cell cycle DNA replication initiation. Each is linked with FANCE in more than 14 cancer types. Because this analysis shows association rather than direction, both FANCE-to-partner and partner-to-FANCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interstrand cross-link repair grouped by FANCE-low versus FANCE-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCE→partner) and Y-score (partner→FANCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Interstrand cross-link repair →	+0.104	+1.147	.001	<.001	3	15
CNS	Negative regulation of RNA export from nucleus →	+0.118	+0.708	<.001	<.001	3	15
SOFT_TISSUE	Cell cycle DNA replication initiation →	+0.177	+0.966	<.001	<.001	3	15
SOFT_TISSUE	Nuclear cell cycle DNA replication initiation →	+0.177	+0.966	<.001	<.001	3	15
SOFT_TISSUE	Mitotic DNA replication initiation →	+0.177	+0.966	<.001	<.001	3	15
BONE	DNA strand elongation involved in DNA replication →	+0.252	+1.302	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,734 associations by consensus.

Interstrand cross-link repair by FANCE expression — BONE

Explore this box plot interactively →