FANCD2

Across TCGA patient cohorts, FANCD2 RNA expression is significantly associated with the protein abundance of many other proteins, with 25,312 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FANCD2-associated proteins across cancer lineages are POLD1, RRM2, and SMC2. Each is linked with FANCD2 in more than 9 cancer types. Because this analysis shows association rather than direction, both FANCD2-to-partner and partner-to-FANCD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FANCD2 versus POLD1 in UCEC, with a Pearson correlation of 0.61.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCD2→partner) and Y-score (partner→FANCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLD1 →	+0.351	+0.795	<.001	<.001	3	10
LUAD	RRM2 →	+0.783	+0.701	<.001	<.001	3	10
GBM	SMC2 →	+0.779	+0.951	<.001	<.001	3	10
GBM	SMC4 →	+0.747	+0.965	<.001	<.001	3	10
BRCA	CDC20_T70 →	+1.026	+0.719	<.001	<.001	3	10
UCEC	CDK1 →	+0.749	+0.919	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,312 associations by consensus.

FANCD2 vs POLD1 — UCEC

Explore this scatter interactively →