FANCC

Across TCGA patient cohorts, FANCC mutation is significantly associated with the RNA expression of many other genes, with 2,115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FANCC-associated genes across cancer lineages are MIR6780B, RNA5SP297, and TUBB4BP5. Each is linked with FANCC in more than 2 cancer types. Because this analysis shows association rather than direction, both FANCC-to-partner and partner-to-FANCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6780B grouped by FANCC-low versus FANCC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCC→partner) and Y-score (partner→FANCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6780B →	+0.518	+3.711	<.001	.003	3	3
HNSC	RNA5SP297 →	+0.891	+5.069	<.001	<.001	3	3
LUSC	TUBB4BP5 →	+0.098	+5.438	<.001	<.001	3	3
CESC	LINC01519 →	+0.024	+5.669	<.001	.003	3	2
UCEC	TRAJ47 →	+0.470	+2.105	<.001	<.001	3	2
BLCA	IGHD3-16 →	+0.999	+3.293	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,115 associations by consensus.

MIR6780B by FANCC expression — SKCM

Explore this box plot interactively →